A Few Examples The tricyclic antidepressants, also known as TCAs or "trycyclis", are effective for the treatment of depression, and are often used to treat nerve pain and to prevent migraine headaches. However, TCAs may reduce the amount of vitamin B2 and Co-enzyme Q10 in the body. Vitamin B2, also known as riboflavin, is a water-soluble vitamin needed for metabolism, cellular energy production, hair and nail growth and is also an antioxidant. Signs of vitamin B2 deficiency may include cracked and burning skin, burning of lips, mouth and tongue, redness and burning of the eyes, and dry or scaly skin. Co-enzyme Q10, also known as ubiquinone, is a fat-soluble vitamin needed by the body. Co-enzyme Q10 is needed in all cells for the production of energy. The effects of Co-enzyme Q10 depletion are seen particularly in the cardiovascular system because the heart has higher energy needs that most other parts of the body. Some common symptoms of Co-enzyme Q10 deficiency can include lack of energy, high blood pressure, heart problems, and weakened immune system.

Doses of 1 to 100 mg per day have been suggested for vitamin B2 supplementation. For Co-enzyme Q10, doses of 30 to 200 mg per day have been suggested.

Talk to your doctor or pharmacist about taking vitamin B2 or Co-enzyme Q10 if you are taking a tricyclic antidepressant.